[news]紫外线钉灯的使用与皮肤癌发病风险无关

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紫外线钉灯的使用与皮肤癌发病风险无关

研究显示，人工紫外线钉灯不会显著的提高角化细胞癌的发生率。

Alina Markova（马萨诸塞州综合医院，波士顿，美国）与Martin Weinstock（布朗大学阿尔伯特医学院，罗德岛，美国）说，“虽然某些光源发出的紫外线A和紫外线B会引发角化细胞癌的发生，但是，紫外线钉灯似乎没有明显的增加角化细胞癌终生患病风险。”

研究人员将紫外线钉灯发出的紫外线辐射影响与光疗设备的紫外线辐射作比较。窄谱紫外线在皮肤病治疗中有着很广泛的应用，被视为一种低概率引发角化细胞癌的光波。

测试了三种型号的紫外线钉灯：设备A由四个9W紫外荧光灯泡组成，设备B由一个9W紫外荧光灯泡组成，设备C由6个1W的发光二极管紫外灯组成。

这三种类型钉灯的波长、瓦数、光谱辐照度，被认为是现今使用设备标准的代表。

Markova 和 Weinstock 使用了光致癌作用光谱（皮肤癌乌德勒支费城人【SCUP-h】）标准来判断紫外线钉灯与单NBUVB光疗疗程的潜在致癌率。

研究人员将他们的比较实验建立在，在一个5~10周、15~30次的单NBUVB疗程中，一个病人受到 25 J/cm2 的紫外线积累量的基础上。

他们发现，需要使用超过13000个设备 A或者设备B及40000个设备C的紫外线钉灯一起照射10分钟才能与一次NBUVB疗程的紫外线量相同。

这意味着，一个人将要在250年中每周经历一次紫外线钉灯照射才能与一次NBUVB疗程暴露索带来的致癌风险相同。

作者写道，“我们对于三种类型的紫外线钉灯的研究显示，一次紫外线钉灯暴露的量只等同于一次NBUVB 疗程非常小的一部分，因此，今后将不认为其能显著提高皮肤癌的发病率。”

他们说：“皮肤病学家和初级保健师能消除病人对于这些设备安全的的疑虑。”

这项研究发表在Journal of Investigative Dermatology上。

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UV nail lamp use not associated with skin cancer risk

Research shows that artificial ultraviolet (UV) nail lamps do not significantly increase the risk for developing keratinocyte carcinoma.

"Although some sources of UVA and UVB contribute to the development of KCs [keratinocyte carcinomas], UV nail lamps do not appear to significantly increase the lifetime risk of KC," say Alina Markova (Massachusetts General Hospital, Boston, USA) and Martin Weinstock (Alpert Medical School of Brown University, Rhode Island, USA).

They compared the effect of UV radiation emitted by UV nail lamps with that of phototherapy devices. Narrow band UVB (NBUVB) used for phototherapy is a commonly used dermatologic treatment, viewed as low risk for the development of keratinocyte carcinoma.

Three UV nail lamp devices were tested: device A consisted of four 9W UV fluorescent bulbs, device B consisted of one 9W UV fluorescent bulb, and device C consisted of six 1W light-emitting diode UV lights.

The wavelengths, wattages, and spectral irradiance of these three nail lamps were considered representative of standard devices used in the field.

Markova and Weinstock used the action spectrum for photocarcinogenesis (Skin Cancer Utrecht-Philadelphia human [SCUP-h]) to determine the ratio between the carcinogenic potential of the UV nail lamps and the single NBUVB phototherapy course.

The researchers based their comparison on the assumption that a patient would receive a cumulative UV dose of 25 J/cm2 during a single NBUVB course of 15-30 treatments over a period of 5-10 weeks.

They found that over 13,000 10-minute UV nail lamp sessions with device A or B and more than 40,000 with device C would be required to equal the UV dose received during one course of NBUVB treatment.

This means that an individual would have to undergo over 250 years of weekly UV nail sessions to equal the same risk exposure from one course of NBUVB.

"Our study of three UV nail lamps reveals that such exposure is a tiny fraction of a single NBUVB course, and hence does not produce a clinically significant increased risk of developing skin cancer," write the authors.

"Dermatologists and primary-care physicians may reassure patients regarding the safety of these devices," they say.

The study findings are published in the Journal of Investigative Dermatology.